查看全文
，今年12月刚发表的
Neurological Manifestations of hospitalized patients with mild to moderate infection with SARS-CoV-2 Omicron variant in Shanghai, Chinawww.sciencedirect.com/science/article/pii/S1876034122003458
先贴此研究的结论：
这个比较其它高得吓人
Omicron甚至比武汉2019年原始毒株更容易引发脑功能障碍
2022年11月Nature上发表的一篇研究比较了Omicron与之前变种在入侵大脑的能力上的不同：
Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids
“Here, we investigated the neuroinvasion and neurotoxicity of Omicron BA.1 and BA.2, and compared the findings with those of SARS-CoV-2 WT and Delta in human forebrain and midbrain organoids. Our results demonstrated that BA.2 replicated more efficiently while triggered lower levels of type I interferon response than that of SARS-CoV-2 WT, Delta, and BA.1 in both human forebrain and midbrain organoids. In addition, BA.2 triggered substantially higher levels of apoptosis in the infected human forebrain and midbrain organoids. Together, these findings suggest that BA.2 may be different from SARS-CoV-2 WT and previous variants in its capacity in targeting and causing